Experiences fresh advancements and growth within the carbohydrate-related chemistry of novel nucleic acid mimics and their functions in antisense therapeutics. Discusses using new chemical sessions to rationally layout and synthesize oligonucleotides. Explores a number of carbohydrate transformations of the oligonucleotide to stabilize opposed to nuclease degradation and to reinforce the binding affinity for a given objective. indicates destiny instructions of carbohydrate-related changes for antisense molecules.
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